|
Symbol Name ID |
Lbr
lamin B receptor MGI:2138281 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgM level |
Abnormal leukocyte morphology |
Neutropenia |
Abnormality of neutrophils |
Hyposegmentation of neutrophil nuclei |
Splenomegaly |
Hepatosplenomegaly |
Celiac disease |
Gastrointestinal inflammation |
Hepatitis |
Recurrent otitis media |
Eczematoid dermatitis |
Autoimmunity |
Antimitochondrial antibody positivity |
Antinuclear antibody positivity |
Recurrent fungal infections |
Onychomycosis |
| Disease(s) Associated with LBR | ||||||||||||||||||
| Greenberg dysplasia | ||||||||||||||||||
| Pelger-Huet anomaly | ||||||||||||||||||
| primary biliary cholangitis |
| Mouse Phenotypes | abnormal granulocyte differentiation |
abnormal neutrophil differentiation |
decreased T cell proliferation |
thymus hypoplasia |
enlarged spleen |
abnormal eosinophil morphology |
abnormal granulocyte morphology |
increased neutrophil cell number |
abnormal neutrophil morphology |
abnormal lymphocyte cell number |
decreased B cell number |
decreased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased T cell number |
decreased lymphocyte cell number |
increased monocyte cell number |
decreased leukocyte cell number |
abnormal lymphocyte morphology |
abnormal spleen morphology |
spleen hypoplasia |
abnormal B cell physiology |
abnormal T cell physiology |
abnormal immune system cell morphology |
enlarged lymph nodes |
lymph node hypoplasia |
increased susceptibility to systemic lupus erythematosus |
increased autoantibody level |
increased anti-nuclear antigen antibody level |
increased anti-chromatin antibody level |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||
| Lbrem1(IMPC)Tcp/Lbrem1(IMPC)Tcp | ||||||||||||||||||||||||||||||
| LbrGt(XE569)Byg/LbrGt(XE569)Byg | ||||||||||||||||||||||||||||||
| Lbric-2J/Lbric-2J | ||||||||||||||||||||||||||||||
| Lbric-3J/Lbric-3J | ||||||||||||||||||||||||||||||
| Lbric-J/Lbric-J | ||||||||||||||||||||||||||||||
| Lbrlym3/Lbrlym3 | ||||||||||||||||||||||||||||||
| Lbric-J/Lbr+ | ||||||||||||||||||||||||||||||
| Lbric-J/Lbrlym3 | ||||||||||||||||||||||||||||||
| Lbrlym3/Lbr+ | ||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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